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"Molecular Farming"
Plant-made Pharmaceuticals and Technical Proteins
edited by
R. Fischer and S. Schillberg
Wiley, December, 2004, 338 pages. $225.00 + shipping ($8.00, U.S. or $15.00 Elsewhere)
Here, authors from academia and industry provide an exciting overview of current production technologies and the fascinating possibilities for future applications. Topics include chloroplast-derived antibodies, biopharmaceuticals and edible vaccines, production of antibodies in plants and plant cell suspension cultures, production of spider silk proteins in plants, and glycosylation of plant produced proteins. The whole is rounded off by chapters on the demands and expectations made on molecular farming by pharmaceutical corporations and the choice of crop species in improving recombinant protein levels. Of interest to biotechnologists, gene technologists, molecular biologists and protein biochemists in university as well as the biotechnological and pharmaceutical industries.
Table of Contents
1. Efficient and Reliable Production of Pharmaceuticals in Alfalfa (Marc-André D’Aoust, Patrice Lerouge, Ursula Busse, Pierre Bilodeau, Sonia Trépanier,Véronique Gomord, Loïc Faye and Louis-Philippe Vézina).
2. Foreign Protein Expression Using Plant Cell Suspension and Hairy Root Cultures (Fiona S. Shadwick and Pauline M. Doran).
3. Novel Sprouting Technology for Recombinant Protein Production (Kimmo Koivu).
4. Monocot Expression Systems for Molecular Farming (Paul Christou, Eva Stoger and Richard M. Twyman).
5. The Field Evaluation of Transgenic Crops Engineered to Produce Recombinant Proteins (Jim Brandle).
6. Plant Viral Expression Vectors: History and New Developments (Vidadi Yusibov and Shailaja Rabindran).
7. Production of Pharmaceutical Proteins in Plants and Plant Cell Suspension Cultures (Andreas Schiermeyer, Simone Dorfmüller and Helga Schinkel).
8. Chloroplast Derived Antibodies, Biopharmaceuticals and Edible Vaccines (Henry Daniell, Olga Carmona-Sanchez and Brittany E. Burns).
9. Plant-derived vaccines: progress and constraints (Guruatma Khalsa, Hugh S. Mason, Charles J. Arntzen).
10. Production of Secretory IgA in Transgenic Plants (Daniel Chargelegue, Pascal M.W. Drake, Patricia Obregon and Julian K.-C.Ma).
11. Production of Spider Silk Proteins in Transgenic Tobacco and Potato (Jürgen Scheller and Udo Conrad).
12. Gene Farming in Pea Under Field Conditions (Martin Giersberg, Isolde Saalbach and Helmut Bäumlein).
13. Host Plants, Systems and Expression Strategies for Molecular Farming (Richard M. Twyman).
14. Downstream Processing of Plant-derived Recombinant Therapeutic Proteins (Juergen Drossard).
15. Glycosylation of Plant-made Pharmaceuticals (Véronique Gomord, Anne-Catherine Fitchette, Patrice Lerouge and Loïc Faye).
16. Biosafety Aspects of Molecular Farming in Plants (Ulrich Commandeur and Richard M. Twyman).
17. A Top-down View of Molecular Farming from the Pharmaceutical Industry: Requirements and Expectations (Friedrich Bischoff).
18. The Role of Science and Discourse in the Application of the Precautionary Approach (Klaus Ammann)
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Agritech Publications/Agricell Report
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Phone/Fax: (914) 528-3469
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