Biopharmaceuticals in Plants

Kathleen Laura Hefferon

January, 2010, 224 pages, Hardcover
Price: $99.95 (Shipping and handling: $8.00 for U.S. delivery, $20.00 elsewhere).

Biopharmaceuticals in Plants provides a comprehensive survey of all major aspects of the development and production of plant-made biopharmaceuticals. Accompanied by an exhaustive list of references to facilitate further study, this critical volume:

* Describes the theory and practice of modern plant transformation techniques with respect to nuclear and plastic genomes

* Outlines the steps involved in the generation of transgenic plants

* Discusses the engineering of plant virus expression vectors for transient expression of vaccine proteins and other therapeutics in plant tissue

* Addresses the significant role of glycosylation in the production of plant-made mammalian proteins

* Investigates the basis of mucosal immunity using plant-based oral vaccines

* Examines the scale-up of plant-derived vaccine and therapeutic proteins in entire crops or in large batch cell suspension cultures

* Explores the development of clinical trials utilizing plant-derived biopharmaceutical proteins

* Evaluates risks and biosafety concerns regarding plant-derived pharmaceuticals

The book concludes with a discussion of the future of plant-based vaccines and other therapeutic proteins with respect to commercial viability and as a tool to improve global public health.

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